The Anti-SSB/La test is a blood test used to detect autoimmune antibodies that are often associated with diseases such as Sjögren’s syndrome and systemic lupus erythematosus (SLE). These antibodies are usually found alongside Anti-SSA/Ro antibodies, although their presence alone is less common. In Sjögren’s syndrome, the presence of Anti-SSB/La together with Anti-SSA/Ro is considered an important diagnostic marker for confirming the disease and is associated with symptoms such as severe dryness of the eyes and mouth. In pregnant women, the presence of these antibodies (especially when accompanied by Anti-SSA/Ro) may increase the risk of transmission to the fetus and complications such as neonatal lupus or congenital heart block. Common diagnostic methods include immunoassays such as ELISA, but the interpretation of results should be done alongside clinical symptoms and other tests, as positivity can rarely be seen in healthy individuals or patients with other autoimmune diseases.
